ABSTRACT
Background: On March 11, 2020, the World Health Organization (WHO) proclaimed Corona-virus Infection 2019 (COVID-19) to be a pandemic. Older subjects and those with underlying medical disorders such hypertension, asthma, diabetes mellitus, chronic lung infection, cardiovascular infections, obesity, and chronic kidney infection have been shown to have a more serious infection course and a greater fatality risk. Aims and Objectives: A study on biochemical parameters of HBV positive individuals suffering from Covid 19 & its effect on their final outcome Material and Methods: The research was conducted in the Department of Biochemistry L.N. Medical College, Bhopal. 200 subjects who are Covid positive will be included in the research. Category-1-60 corona positive subjects who are Hepatitis B virus positive. Category-2-140 corona positive subjects. Results: Out of total 200 covid positive cases, 60 individuals were also HBV positive & rest were only having Covid positive status. When we compared for the pathological/ laboratory diagnostic parameters of all the covid cases, Mean White blood cell Count was more in HBV positive individuals. Lymphocyte count was grossly decreased in HBV positive individuals. Neutrophil count, Platelet count, Alanine aminotransferase, Aspartate aminotransferase, Total bilirubin, Gamma-glutamyltransferase, Alkaline phosphatase, Albumin all these were comparatively on higher side in HBV positive individuals. Conclusion: Cholangiocytes have a role in various immune response-related activities of the hepatic, and when their function is disturbed, it can cause hepatobiliary damage due to a cytopathic effect. The hypothesis that cholangiocytes express more ACE2 receptors than other cell types could help to explain why hepatic function is dysregulated.